We are committed to developing advanced genetically encoded fluorescent indicators to achieve in vivo imaging of small molecular substances, such as metabolites and ions, in model organisms. These biosensors are designed to offer single-cell resolution and high temporal resolution.

Simultaneous detection of multiple chemical substances in living animals represents a key technological frontier. By expressing infrared, red, and green probes in zebrafish, we have achieved concurrent imaging of dopamine, calcium, and ATP, allowing dynamic monitoring during electrical stimulation and epileptic states.